| ncRNA name | NLRP3 shRNA |
| ncRNA Category | shRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal microvascular endothelial cells (HRMECs) |
| Methods | shRNA knockdown, qRT-PCR, Western blot, caspase-3 assay, PI staining |
| Expression pattern | associated |
| Functional description | In high glucose-exposed HRMECs and retinas of diabetic rats, upregulated interleukin (IL)-1β maturation, IL-18 secretion, and caspase-1 cleavage were observed with increased cell apoptosis and retinal vascular permeability. NLRP3 silencing blocked these effects in the rat model and HRMECs. |
| PubMed ID | 27785530 |
| Year | 2017 |
| Title | Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline. |
| Drug-related ncRNA | NA |
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